In Major Breakthrough: Scientists Make Cells Resistant To HIV
Saturday, April 15, 2017
A new discovery will make it possible to identify the blood cells “reservoirs” serving as hiding the AIDS virus and could lead to a remedy.
Hope for the scientific world: a new track has been explored by French researchers to permanently eliminate the AIDS virus from patients.
A marker, to differentiate “dormant” cells infected with HIV, healthy cells, was discovered by scientists.
“This discovery will make it possible to isolate and analyze these reservoir cells which, by silently harboring the virus, are responsible for the persistence of the virus even in patients under antiretroviral treatment, whose viral load is undetectable,” reveals the CNRS The French scientific research institute, in a statement.
Targeting for better extermination
A better understanding of these viral reservoirs harboring the virus would lead to one day better targeting and neutralizing the infectious cells, escaping all research for several decades.
Well hidden and silent, these cells are resistant to the immune system, but also to drugs.
Today, there is no treatment to cure the disease.
Medicines, prescribed for life to patients, are nevertheless useful in stopping the infection: “They prevent the virus from spreading throughout the body … If a patient ceases to take his treatment, the cells” reservoirs ” Wake up and allow the virus to proliferate freely, “.
To consider killing these “invisible” cells, and thus the virus, the scientific team has looked at a protein called “CD32a”, which they now identify. This marker would be present only on the surface of HIV-infected cells, not on healthy cells.
“In the fight against HIV, this discovery paves the way for a better basic knowledge of viral reservoirs, which can now be easily isolated and analyzed directly.
In the longer term, it should lead to therapeutic strategies aimed at eliminating the latent virus from the organism, “the researchers agree, a discovery that makes many scientists dream in this unremitting fight against AIDS.
“The fact that this work was done by skilled researchers, and as the data seem to me to be correct, makes me optimistic,” said the scientist.
Highlighting the importance of the acute phase of infection in HIV transmission is a major breakthrough in the field
It has also been observed that transmission chains favor the propagation of resistant (10%) or multiresistant (3%) strains which may persist for up to 10-15 years after infection.
Since 2004, thanks to the support of our partners, the researchers of the Network have constituted the HITCH cohort to study the viral and host factors favoring the transmission of HPV to study the dynamics of the transmission of the types of HPV between young partners at the beginning Of a new stable heterosexual relationship.
Transmission rates of genital genotypes have recently been described. We have demonstrated that the risk of transmission increases by 50 times with a new sexual partner and that HPV strains are transmitted mainly during the first 4 months of the relationship.
The Primary Infection Cohort has helped to define the viral and immunological factors involved in the onset of HIV infection. Successful intra-network collaborations have led to a better understanding of the pathogenesis of HIV.
For the first time, the role of KIR receptors of NK cells in viral transmission was highlighted.
The HIV-HCV cohort was the subject of a Cohort Profile in the prestigious journal International Journal of Epidemiology.
Our viral genetic studies have demonstrated that the capsid polymorphism of high-risk human papillomavirus is not associated with persistence of infection or presence of HIV infection.
Our viral phylogenetic studies have identified the hypervariable regions of HPVs that are regions prone to immune system pressure and have shown that evolutionary pressure acts primarily on the unexposed regions that maintain the tertiary structure of the capsid.
Saturday, April 15,2017-15:03:11[London]
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